Reviews › GLP-1 Supplements › UK Review 2026
Top 5 supplements for GLP-1 users in the UK
Five options. Five different jobs. Compare the ingredients, daily cost and format at a glance.
James Herd, Nutritionist
Last updated September 2026 · Prices and labels checked 16 September 2026
Our 2026 pick · VYVE Awake
Best overall: one daily cup.
Prebiotic fibre, mushrooms and nootropics in a coffee alternative.
*Three-pack subscription price. Contains caffeine.
Rankings are editorial opinions, not clinical efficacy scores.
Find your fit in seconds
AwakeVYVE76p / servingSee review ↓#2 · Best multivitamin
Vitals⁺Heights£1.33 / servingSee review ↓#3 · Best dedicated fibre
Gut HealthMyota£1.80 / servingSee review ↓#4 · Best for hydration
ElectrolytesSULT£1.20 / servingSee review ↓#5 · Best for muscle
Pure CreatineNutrition Geeks11p / servingSee review ↓The numbers, side by side
Prebiotic fibre per serving
The single most useful number on this list if your gut has slowed down.
Myota is a dedicated fibre and wins this outright. Awake is the only non-fibre product with any at all.
Price per serving
Compare the daily cost.
Awake: three-pack subscription. Heights: £40/month subscription. Creatine: £9.99 for 90 servings. SULT and Myota prices updated 16 September 2026.
How we compared the products
We compared the published ingredients, dose transparency, format and price. Rankings are editorial assessments, not a measure of clinical benefit or suitability for an individual.
The price comparison uses the purchase options stated above. Prices can differ by pack size or subscription.
Common GLP-1 side effects the formula is built for
Out of four: slow gut, bloating, low energy, brain fog. Based on each brand's printed label.
Vitals⁺ carries authorised claims for tiredness and fatigue and cognitive function. Gut Health is fibre for the gut and bloating. SULT's magnesium carries a fatigue claim. Creatine's authorised claim is for physical performance; we've counted it for energy.
Doses printed on the label
Can you see exactly how much of each active you're getting?
Myota lists five fibres and a total but no split between them. Everyone else prints every amount.
Five products. The key points.
#1 · Best overall
Awake by VYVE
Three-pack subscription94%Editorial score
- Coffee alternative with fibre, mushrooms and nootropics.
- 120mg caffeine paired with 200mg L-Theanine.
- One cup in place of your usual morning coffee.
Keep in mind Contains caffeine; less fibre than a dedicated fibre blend.
“I've become more active and thinking a lot clearer as a 67 year old it's fantastic”
Leonard H., verified buyer
Why it wins
Awake takes the top spot because it's the only product here that was built with more than one side effect in mind. The others each do one job well. Awake does three, and it does them in the drink you were going to have anyway.
Pros
- All four common side effects addressed in one serving
- Every dose printed. No blends
- 3g prebiotic inulin — the only coffee alternative with gut fibre
- Citicoline and L-Tyrosine. No other product here has them
- Replaces a habit instead of adding one
- 76p a cup on subscription, with a free Thermal Cup and Whisk
Cons
- Contains caffeine — not for everyone, and not a night-time drink
- It's a powder. You'll want the (free) whisk
- Online only. Not in supermarkets
- Less fibre than a dedicated fibre product
Our take
If you're going to take one thing on a GLP-1, this is the one. It covers the gut, the energy and the fog in a single cup, prints every dose, and slots into the morning you already have. Add Myota if your gut needs more fibre than 3g. Add Vitals⁺ if you're worried about vitamin gaps. But start here.
Shop VYVE AwakeFree UK shipping. Ships in 1 to 2 days.
*VYVE customer survey, 1,000 people, 2026.
#2 · Best multivitamin
Vitals⁺ by Heights
£40 monthly subscription86%Editorial score
- Multivitamin with B vitamins, vitamin D3 and omega-3.
- Every nutrient amount printed on the label.
- A capsule option for people comparing vitamin support.
Keep in mind No fibre; two capsules to take each day.
What it is
Twenty nutrients in two delayed-release capsules a day, including a full B complex, vitamin D3, iron, iodine and an algae-oil omega-3. 4.7 from over 6,000 reviews, free UK shipping and a 30-day guarantee. It's the most credible multivitamin in the UK and the nutrition panel is exemplary.
Why it's here
When you're eating a third of what you used to, vitamin gaps are a real risk, and this is the cleanest way to close them. B vitamins, iron and iodine carry authorised claims for the reduction of tiredness and fatigue, which is the side effect it's honestly built for.
Where it falls short
It does nothing for the gut, nothing for bloating, and the brain-fog case rests on nutrients rather than the nootropic doses Awake uses. At £40 a month, it costs £1.33 per serving.
Pros
- Twenty nutrients, every dose and NRV printed
- Authorised claims for tiredness, fatigue and cognitive function
- Two small capsules, with or without food
- 4.7 from 6,000+ reviews. 30-day guarantee
Cons
- No fibre, nothing for the gut or bloating
- £1.33 a day on subscription
- Capsules on a nauseous morning are a harder sell than a drink
- Subscription-led; one-off purchase means going through a stockist
Our take
The multivitamin we'd pick if you want one. It solves a different problem from Awake — nutrient gaps rather than day-to-day side effects — and the two stack well. On its own, it leaves the gut untouched.
#3 · Best dedicated fibre
Gut Health by Myota
Per serving84%Editorial score
- The highest fibre serving in this comparison.
- Flavourless powder to stir into a drink or meal.
- Low-FODMAP certified.
Keep in mind Build up gradually; individual fibre amounts are not listed.
What it is
A five-fibre blend — PHGG, gluten-free wheat and oat fibre, guar and cellulose — with 9.8g of fibre in a 10g scoop, plus zinc. Flavourless, stirs into anything, and it's the only fibre blend certified low FODMAP by Monash University. 4.5 from 662 reviews, 30-day guarantee.
Why it's here
If a slow gut is your main problem, this has more fibre per serving than anything else on the list, and the low-FODMAP certification matters if you're the kind of person inulin upsets. Myota's own four-week survey of 293 customers reported 93% had more regular bowel movements and 80% felt less bloated.
Where it falls short
You have to build up from half a scoop over a week, which is one more thing to manage. The label lists five fibres but not how much of each. And it's fibre only — nothing for energy or fog, and it needs a drink or a meal to carry it.
Pros
- 9.8g fibre per serving — three times Awake
- Monash low FODMAP certified. Gentle on sensitive guts
- Flavourless; goes in anything
- Brand survey: 93% more regular after four weeks
Cons
- Five fibres, no individual amounts
- Needs a week-long build-up
- Fibre and zinc only — nothing for energy or focus
- Another product to remember, not a habit you already have
Our take
The fibre we'd add to Awake if 3g isn't enough. As a standalone it's a strong, well-tolerated fibre — but it's one side effect out of four, and it asks you to remember it.
#4 · Best for hydration
Electrolytes by SULT
Per serving78%Editorial score
- Single-serve electrolyte sachets to mix with water.
- Contains sodium, potassium, calcium and magnesium.
- Every electrolyte amount printed on the label.
Keep in mind 500mg sodium per sachet; no fibre.
What it is
Zero-sugar electrolyte sachets with all six essentials — 500mg sodium, 304mg potassium, 120mg calcium, 100mg magnesium, chloride and phosphorus — plus coconut water powder, sweetened with stevia. 26 sachets a box, made in the UK, stocked in Boots, 30-day guarantee.
Why it's here
Nausea, less food and less fluid add up to dehydration, and a lot of what feels like GLP-1 fatigue is partly that. SULT's magnesium carries an authorised claim for the reduction of tiredness and fatigue, and a sachet in water is about the easiest thing to get down on a bad day.
Where it falls short
It's hydration. It does nothing for the gut, the bloating or the fog. The sodium is generous — fine if you're sweating or under-eating, worth a thought if you're watching blood pressure.
Pros
- All six electrolytes, every amount printed
- Zero sugar, no artificial sweeteners
- Easiest format here on a nauseous morning
- In Boots as well as online
Cons
- One side effect out of four
- 500mg sodium per sachet is a lot if you're not sweating
- Stevia — some people notice it
- 26 sachets, not 30, so a box doesn't quite last a month
Our take
A good electrolyte and a sensible thing to have in the drawer for jab day. But it's an add-on, not a foundation.
#5 · Best for muscle
Pure Creatine by Nutrition Geeks
£9.99 / 90 servings72%Editorial score
- Pure creatine monohydrate with no added ingredients.
- Unflavoured powder that mixes into a drink.
- The lowest price per serving in this comparison.
Keep in mind Designed around exercise performance; no fibre.
What it is
315g of micronised creatine monohydrate — one ingredient, 3.5g a day, 90 servings — for £9.99 with free UK delivery. Unflavoured, vegan, third-party tested. Nothing else in the bag.
Why it's here
Muscle loss is the GLP-1 side effect people don't notice until it's happened. Creatine at 3g a day carries an authorised claim for increasing physical performance in short bursts of high-intensity exercise, and it's the cheapest useful thing on this list by a mile.
Where it falls short
It's a single job. It does nothing for the gut, bloating or fog, the claim only applies if you're actually training, and creatine only works if you take it every day — another scoop to remember.
Pros
- 11p a day. Cheapest here by far
- One ingredient, dose printed, third-party tested
- Authorised claim at 3g/day for physical performance
- Mixes into anything, including Awake
Cons
- One side effect, and only if you're exercising
- Nothing for gut, bloating or fog
- Needs daily consistency to do anything
- Some people notice water retention in the first weeks
Our take
If you're lifting while you lose weight, buy it — it's £10. If you're not, it won't touch the side effects that brought you here.
Our overall pick
Make it part of your morning.
VYVE Awake combines prebiotic fibre with mushrooms and nootropics in a daily coffee alternative.
Explore VYVE Awake76p per serving on the three-pack subscription. Contains caffeine.
No supplement replaces meals or prescribed treatment. Check with your prescriber before adding supplements. Customer survey results quoted in the expanded reviews are self-reported; individual experiences vary.